SoftPro project will study and design soft synergy-based robotics technologies to develop new prostheses, exoskeletons, and assistive devices for upper limb rehabilitation, which will greatly enhance the efficacy and accessibility to a greater number of users. Building on solid methodological bases, SoftPro will produce a significant social impact, promoting advanced robot prosthetic and assistive technology “from bench to bedside”; but it will also introduce disruptively new, admittedly risky but potentially high-impact ideas and paradigms.